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Sample Preparation in Genomics, Proteomics, and Epigenomics: Global Markets

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Sample Preparation in Genomics, Proteomics, and Epigenomics: Global Markets

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STUDY GOALS AND OBJECTIVES

This BCC Research report, Sample Preparation in Genomics, Proteomics, and Epigenomics: Global Markets, provides an overview of the current overall state of the sample preparation industry for life science research focusing on the genomics, epigenomics and proteomics segments. It describes existing products on the market, and a detailed analysis of the competitive environments, including new potential markets for novel products and assay development. This study includes information about significant players, trends, and obstacles and other information affecting this market and its different segments.

REASONS FOR DOING THIS STUDY

Experimental procedure and technical protocols are the basis for a successful scientific project. Sample preparation steps are often the main "bottleneck" or foundation for further downstream analysis and workflow.
Reagents companies started to recognize commercial potential in providing the required reagents, kits and assays that help to facilitate scientific work by reducing time, labor and even costs. Slowly, sample preparation products are evolving into a specific market space with its own trends, influences and challenges.
Although it is part of the life science reagents and tools industry in general, the sample preparation segment exhibits specific characteristics and differences in its market participants and competitive landscape.
This REPORT HIGHLIGHTS the main segments in the sample preparation industry: genomics, proteomics and epigenomics. It discusses its major players, current and future trends, and influences. Drivers and challenges in each segment of this industry are described in detail, including forecasts for the next five years.

SCOPE AND FORMAT

This report is essentially a business tool that can help market players evaluate new commercial opportunities in the sample preparation market for genomics, proteomics and epigenomics research. The geographic scope of this study is global. This market is complex and consists of many different segments, each of which is affected differently by scientific and technological developments. This report identifies the main positive and negative factors affecting each segment, and forecasts market growth, future trends, and product and assay development in every major segment of this market.

METHODOLOGY AND INFORMATION SOURCES

Both primary and secondary research methodologies were used in preparing this study. Initially, a comprehensive and exhaustive search of the literature on drug discovery and already marketed products was conducted. These secondary sources included drug discovery and science-related journals, textbooks, press releases, marketing literature, other product/promotional literature, annual reports, security analyst reports and other publications. A patent search and analysis were also conducted.
In a second phase, a series of semistructured interviews was conducted with company representatives, bench scientists, marketing representatives and other personnel at biotechnology and pharmaceutical companies. Other sources included academics, technology and consulting companies. Subsequent analysis of the documents and interviews notes was iterative.

INTENDED AUDIENCE

This report is intended for business development professionals, entrepreneurs and other investors who need to fully understand and properly evaluate each segment of the market for sample preparation in genomics, proteomics and epigenomics research. It provides insights into the market positions of major companies, and shows new opportunities otherwise overlooked or less known to the business community.

ANALYST'S CREDENTIALS

Jackson Highsmith is a life sciences research consultant with more than 16 years of research experience. Jackson has been consulting with specialty pharmaceuticals and large pharmaceutical industry players since 2007. Prior to that, he worked at a large research consultancy where he focused on in-depth research; he also has worked at a large pharmaceutical company dealing with a wide range of medical therapeutics in early and midstage drug development.

REPORT HIGHLIGHTS

This report provides:
• An overview of the global market for sample preparation reagents and products used in life science research.
• Analyses of global market trends, with data from 2012, estimates for 2013, and projections of compound annual growth rates (CAGRs) through 2018
• Estimates of demand for various sample preparation reagents and products.
• Analysis of target markets for sample preparation by application
• Information on labeling and probes in the sample preparation market
• Comprehensive company profiles of major players.

TABLE OF CONTENTS

CHAPTER 1 INTRODUCTION 2

STUDY GOALS AND OBJECTIVES 2
REASONS FOR DOING THIS STUDY 2
SCOPE AND FORMAT 2
METHODOLOGY AND INFORMATION SOURCES 2
INTENDED AUDIENCE 3
ANALYST'S CREDENTIALS 3
RELATED BCC REPORTS 3
BCC ONLINE SERVICES 4
DISCLAIMER 4

CHAPTER 2 SUMMARY 6

SUMMARY TABLE GLOBAL MARKET FOR SAMPLE PREPARATION REAGENTS AND
PRODUCTS USED IN LIFE SCIENCE RESEARCH BY SEGMENT, THROUGH 2018 ($
MILLIONS) 6
SUMMARY FIGURE GLOBAL MARKET FOR SAMPLE PREPARATION REAGENTS AND
PRODUCTS USED IN LIFE SCIENCE RESEARCH BY SEGMENT, 2010-2018 ($
MILLIONS) 6

CHAPTER 3 INTRODUCTION TO THE SAMPLE PREP MARKET 10

OVERVIEW 10
TABLE 1 GLOBAL MARKET FOR COMMON REAGENTS AND PRODUCTS IN THE LIFE
SCIENCE TOOLS INDUSTRY BY SEGMENT, THROUGH 2018 ($ BILLIONS) 10
FIGURE 1 GENOME AND GENE ANALYSIS WORKFLOW 11
FIGURE 2 PROTEIN ANALYSIS WORKFLOW 12
MAJOR TRENDS AND DRIVERS IN THE SAMPLE PREP SEGMENT OF THE LIFE
SCIENCE TOOLS INDUSTRY 12
BIOMARKER RESEARCH AND DIAGNOSTICS INDUSTRY 12
INNOVATIVE TECHNOLOGIES AND SCIENTIFIC TRENDS 12
Next-Generation Sequencing 12
Scientific Trends 13
Stem Cell Research 13
Epigenomic Research 13
GOVERNMENT POLICIES AND FUNDING 13
MAIN MARKET PARTICIPANTS IN THE SAMPLE PREP INDUSTRY 14
TABLE 2 GLOBAL MARKET SHARES OF THE SAMPLE PREP INDUSTRY BY LIFE
SCIENCE RESEARCH SEGMENT, 2013 (%) 15
GEOGRAPHIC DISTRIBUTION OF THE SAMPLE PREP MARKET 16
TABLE 3 GLOBAL MARKET SHARES OF THE SAMPLE PREP INDUSTRY BY
GEOGRAPHIC REGION, 2013 (%) 16
TECHNOLOGY PATENTS IN THE SAMPLE PREP INDUSTRY 16
TABLE 4 PRIOR ART FOR ILLUMINA'S NEWLY ACQUIRED ALL TECHNOLOGY: LAB ON
A CHIP 19

CHAPTER 4 SAMPLE PREPARATION PRODUCTS FOR GENOMICS RESEARCH 21

OVERVIEW 21
GENOMICS STUDIES AS A MARKET FOR THE LIFE SCIENCE TOOLS AND SAMPLE
PREPARATION INDUSTRIES 22
TABLE 5 GLOBAL MARKET FOR GENOMICS PRODUCTS, THROUGH 2018 ($ BILLIONS) 23
PRODUCTS FOR SAMPLE PREPARATION IN GENOMICS 23
NUCLEIC ACID EXTRACTION/PURIFICATION MARKET 23
Overview 23
Magnetic Bead Based Nucleic Acid Purification 25
Anion Exchange Approach for Nucleic Acid Purification 25
All-in-One Application Products 26
Nucleic Acid Extraction Market Evaluation 26
TABLE 6 GLOBAL MARKET VALUE OF NUCLEIC ACID EXTRACTION PRODUCTS,
THROUGH 2018 ($ MILLIONS) 26
Main Participants in the Nucleic Acid Extraction Market 27
TABLE 7 NUCLEIC ACID MARKET SHARES BY COMPANY, 2013 (%) 28
Primary Types of End Users in the Nucleic Acid Preparation Market 28
TABLE 8 DISTRIBUTION OF THE NUCLEIC ACID PREPARATION MARKET BY TYPE OF
END USER, 2013 (%) 29
TABLE 9 GEOGRAPHIC DISTRIBUTION OF THE NUCLEIC ACID PREPARATION
MARKET, 2013 (%) 29
SPECIFIC NICHES AND SUBMARKETS IN THE NUCLEIC ACID ISOLATION
MARKET 29
RNA Extraction and Purification Products 29
TABLE 10 GLOBAL MARKET SHARES OF RNA ISOLATION PRODUCTS BY COMPANY,
2013 (%) 31
miRNA as a New Trend in Research Tools Development and Nucleic
Acid Purification Market 32
Formalin Fixed Paraffin-Embedded Tissues as a Submarket of the
Nucleic Acid Purification Market 33
TABLE 11 SELECT COMPANIES PROVIDING PRODUCTS FOR FFPE NUCLEIC ACID
EXTRACTION 34
Market for Nucleic Acid Extraction from Biological Samples 35
Nucleic Acid Extraction from Difficult Samples (Plants, Fungi, Yeast) 36
INNOVATIVE TECHNOLOGIES IN THE NUCLEIC ACID PURIFICATION MARKET 36
Cell Lysis and Expression Analysis without Isolating RNA 37
Single-Cell Analysis 37
Quantification of Dried Blood Spots 37
Specialized Applications 37
AUTOMATION ASPECT OF THE NUCLEIC ACID PREPARATION MARKET 38
TABLE 12 DISTRIBUTION OF AUTOMATION DEVICES FOR NUCLEIC ACID
PURIFICATION BY TYPE OF END USER, 2013 (%) 39
TABLE 13 COMPANIES THAT PROVIDE NUCLEIC ACID SAMPLE PREPARATION
PLATFORMS 39
SUMMARY OF THE NUCLEIC ACID EXTRACTION MARKET 41
TABLE 14 AVERAGE PRICES OF NUCLEIC ACID PURIFICATION UNITS OFFERED BY
REPRESENTATIVE COMPANIES, 2013 ($) 41
SAMPLE PREPARATION FOR DNA AMPLIFICATION AND POLYMERASE CHAIN
REACTION 42
OVERVIEW 42
TABLE 15 GLOBAL DNA AMPLIFICATION/PCR MARKET, THROUGH 2018 ($ BILLIONS) 42
TABLE 16 GLOBAL RT-PCR MARKET SHARES BY COMPANY, 2013 (%) 43
TABLE 17 GLOBAL PCR MAKET SHARES BY GEOGRAPHIC REGION, 2013 (%) 44
NEW TRENDS AND DEVELOPMENTS IN THE PCR MARKET 44
Digital PCR Trend 44
Direct PCR 45
SAMPLE PREPARATION PRODUCTS IN THE PCR MARKET 45
TABLE 18 SAMPLE PREPARATION MARKET ESTIMATE FOR PCR APPLICATIONS,
THROUGH 2018 ($ MILLIONS) 46
SAMPLE PREPARATION MARKET FOR SEQUENCING APPLICATIONS 48
SEQUENCING IN THE RESEARCH TOOLS MARKET 49
TABLE 19 GLOBAL MARKET FOR DNA SEQUENCING, THROUGH 2018 ($ BILLIONS) 50
TABLE 20 GLOBAL MARKET FOR NGS AND GENERAL SEQUENCING, THROUGH 2018
($ BILLIONS) 51
TABLE 21 NGS MARKET SHARES BY COMPANY, 2013 (%) 53
SAMPLE PREPARATION FOR NGS EVOLVES AS A COMPETITIVE MARKET 53
Overview 53
TABLE 22 CRITERIA FOR CHOOSING A SPECIFIC VENDOR FOR SAMPLE PREP IN NGS
ACCORDING TO PRIORITY (%) 54
TABLE 23 VALUE OF NGS FOR THE SAMPLE PREP MARKET, THROUGH 2018 ($
MILLIONS) 55
Drivers and Challenges for the Sample Preparation Industry in NGS 55
LIBRARY CONSTRUCTION 56
DNA 56
RNA Sample Preparation 56
mRNA 56
Small RNA 56
TABLE 24 RECENT ACQUISITIONS AND COLLABORATIONS IN THE NGS SAMPLE
PREP INDUSTRY, 2013 57
SAMPLE PREPARATION PRODUCTS FOR CLONING AND DNA ASSEMBLY 58
OVERVIEW 58
TABLE 25 MARKET ESTIMATION FOR SAMPLE PREPARATION IN MOLECULAR
CLONING, THROUGH 2018 ($ MILLIONS) 59
SYNTHETIC BIOLOGY TREND AS A POSITIVE DRIVER IN THE SAMPLE
PREPARATION MARKET 60
ADDITIONAL TARGET SUBMARKETS FOR SAMPLE PREPARATION PRODUCTS FOR
GENOMICS 61
DNA MICROARRAYS 61
TABLE 26 GLOBAL MARKET FOR DNA MICROARRAYS, THROUGH 2018 ($ BILLIONS) 62
RNA RESEARCH AND ITS SAMPLE PREPARATION MARKET 62
Overview 62
RNA Products 62
RNA Extraction Purification Kits 63
RNA Synthesis, Degradation and Modification Products 63
TABLE 27 SELECT RNA SYNTHESIS, DEGRADATION AND MODIFICATION PRODUCTS 63
RNA Interference 63
TABLE 28 GLOBAL RNA INTERFERENCE MARKET, THROUGH 2018 ($ MILLIONS) 64

CHAPTER 5 SAMPLE PREP PRODUCTS FOR EPIGENOMICS 67

OVERVIEW 67
TABLE 29 GLOBAL MARKET FOR DRUG DISCOVERY IN EPIGENOMIC RESEARCH,
THROUGH 2018 ($ BILLIONS) 69
DNA METHYLATION 69
DNA METHYLATION DETECTION TECHNIQUES 71
HISTONE MODIFICATIONS 72
TABLE 30 DIFFERENT CLASSES OF MODIFICATIONS IDENTIFIED ON HISTONES 72
EPIGENOMIC RESEARCH TOOLS AND PRODUCTS, INCLUDING THE SAMPLE
PREPARATION MARKET 73
TABLE 31 SELECT EPIGENOMIC PRODUCTS BY SUPPLIER 73
DNA Methylation Research and Sample Preparation Products 73
Histone Methylations and Modifications and Sample Preparation
Products 75
TABLE 32 SELECT EPIGENOMIC SAMPLE PREPARATION PRODUCTS BY SUPPLIER 75
MARKET FOR EPIGENOMICS REAGENTS AND SAMPLE PREPARATION TOOLS 75
TABLE 33 PRODUCT CATEGORIES FOR EPIGENOMICS RESEARCH, COMPANIES
MARKETING THE PRODUCTS AND AVERAGE PRICES 76
TABLE 34 PERCENTAGE OF COMMERCIAL KITS GENERALLY PURCHASED FOR
EPIGENOMIC RESEARCH BY PRODUCT TYPE (%) 77
TABLE 35 GLOBAL MARKET RESEARCH TOOLS IN THE EPIGENOMIC SEGMENT,
THROUGH 2018 ($ BILLIONS) 77
ESTIMATED MARKET POTENTIAL FOR NEW EPIGENOMICS PRODUCTS 78
TABLE 36 DISTRIBUTION OF EPIGENOMIC PRODUCTS IN THE U.S. SAMPLE
PREPARATION INDUSTRY BY TYPE OF END USER, 2013 (%) 78
Selected Market Participants in Assay Development for HMT Activity 79
Perkin Elmer 79
G Bioscience 80
Epigentek 80
Cayman Chemical 81
BPS Bioscience 81
Reaction Biology 81
BellBrook Labs 82
Abcam 82
CisBio Bioassays 82
TABLE 37 STUDIES AND ASSAY DEVELOPMENT IN SPECIFIC DISEASE AREAS (%) 83
Active Motif 84
Biocius 85
BPS Bioscience 85
Cayman Chemical 86
EMD Millipore 86
Epigentek 87
Life Technologies 87
Perkin Elmer 87
Reaction Biology 88
TABLE 38 GLOBAL MARKET FOR RESEARCH TOOLS, REAGENTS AND ASSAYS FOR
HISTONE METHYLTRANSFERASE STUDIES, THROUGH 2018 ($ MILLIONS) 89
TABLE 39 SURVEY OF USER-SCIENTISTS' OPINIONS ABOUT EPIGENETICS
SCREENING IN DRUG DISCOVERY (%) 89

CHAPTER 6 PROTEOMICS RESEARCH AS A MARKET FOR THE SAMPLE PREPARATION

INDUSTRY 91
OVERVIEW 91
TABLE 40 GLOBAL MARKET FOR PROTEOMICS TOOLS, THROUGH 2018 ($ BILLIONS) 92
PROTEIN EXPRESSION AS A TARGET MARKET FOR SAMPLE PREPARATION
PRODUCT DEVELOPMENT 92
Overview 92
TABLE 41 PERCENTAGE USE OF SPECIFIC PROTEIN EXPRESSION TECHNIQUES,
2013 (%) 93
Prokaryotic Expression Systems 93
Mammalian Expression Systems 94
Protein Expression in Insect Cell Systems 94
Protein Expression in Yeast Cell Systems 94
Protein Expression in Plant Cell Systems 94
Cell-Free Systems 95
PROTEIN EXPRESSION AND SAMPLE PREPARATION MARKET PARTICIPANTS 95
TABLE 42 PROTEIN EXPRESSION MARKET SHARES BY COMPANY, 2013 (%) 96
SAMPLE PREPARATION AND THE PROTEIN PURIFICATION MARKET 96
Overview 96
Extraction, Cell Lysis Procedure and Protein Solubilization 97
Protein Purification: Precipitation and Differential Solubilization 98
Protein Purification: Chromatographic Methods 98
Size Exclusion Chromatography 98
Separation Based on Charge or Hydrophobicity 99
Affinity Chromatography 99
Immunoaffinity Chromatography 99
High-Performance Liquid Chromatography 100
TABLE 43 GLOBAL MARKET FOR PROTEIN CHROMATOGRAPHY, THROUGH 2018 ($
MILLIONS) 100
TABLE 44 AVERAGE SPENDING PER SCIENTIST ON PURIFICATION/ SEPARATION
PRODUCTS ($) 101
SAMPLE PREPARATION FOR PROTEIN IDENTIFICATION AND
CHARACTERIZATION TECHNIQUES 102
Mass Spectrometry 102
TABLE 45 GLOBAL MARKET FOR MASS SPECTROMETRY, THROUGH 2018 ($
MILLIONS) 102
Protein Sequencing Approach 104
ICAT 104
MudPit 104
X-ray Crystallography 104
Protein Nuclear Magnetic Resonance (NMR) 105
TABLE 46 PERCENTAGE OF TOTAL NMR APPLICATIONS IN VARIOUS SECTORS, 2013
(%) 105
ADDITIONAL RESEARCH TOOLS IN PROTEOMICS STUDIES AND THEIR
SAMPLE PREPARATION PRODUCTS 106
Two-Dimensional Gel Electrophoresis and Its Alternatives 106
TABLE 47 GLOBAL MARKET FOR 2D GEL ANALYSIS, THROUGH 2018 ($ MILLIONS) 106
TABLE 48 EXAMPLES OF 2D GEL SAMPLE PREPARATION PRODUCTS BY COMPANY,
2013 ($) 107
Protein-Protein Interaction Identification Techniques 108
Protein Microarrays 109
TABLE 49 GLOBAL PROTEIN CHIP MARKET, THROUGH 2018 ($ MILLIONS) 110
GENERAL MARKET OVERVIEW FOR SAMPLE PREPARATION IN PROTEOMICS
RESEARCH 110
TABLE 50 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
PROTEOMICS, THROUGH 2018 ($ MILLIONS) 111
Market Participants in Proteomics Sample Preparation 111
TABLE 51 CATEGORIES IN THE SAMPLE PREPARATION MARKET FOR PROTEOMICS
RESEARCH AND EXAMPLES OF MARKET PARTICIPANTS 112
TABLE 52 EXAMPLES OF SAMPLE PREPARATION SERVICES FOR PROTEOMICS
RESEARCH AND THEIR AVERAGE COSTS ($) 112
TABLE 53 DISTRIBUTION OF THE PROTEOMICS SAMPLE PREPARATION MARKET BY
TYPE OF END USER, 2013 (%) 113

CHAPTER 7 LABELING AND PROBES IN THE SAMPLE PREP MARKET 115

OVERVIEW 115
LABELING 115
FLUORESCENT LABELING 115
CHEMILUMINESCENT LABELING 115
RADIOACTIVE LABELING 115
TABLE 54 GLOBAL MARKET FOR VARIOUS LABELING AND PROBES, 2013 ($
BILLIONS) 116
LABELING AND PROBES FOR GENOMICS STUDIES 116
LABELING AND PROBES FOR PROTEOMICS STUDIES 117

CHAPTER 8 SAMPLE PREPARATION FOR THE CELL BIOLOGY REAGENTS MARKET 119

OVERVIEW 119
TABLE 55 GLOBAL MARKET FOR CELL BIOLOGY REAGENTS, THROUGH 2018 ($
BILLIONS) 119
TABLE 56 GLOBAL MARKET SHARES OF CELL BIOLOGY REAGENTS BY PRODUCT
CATEGORY (%) 119
SAMPLE PREPARATION PRODUCTS AND SERVICES IN THE CELL BIOLOGY
SEGMENT 120
Cell Isolation, Maintenance and Banking 120
Flow Cytometry Sample Preparation 121
TABLE 57 GLOBAL MARKET FOR FLOW CYTOMETRY, THROUGH 2018 ($ BILLIONS) 121
Genetic Cell Identification 122
TABLE 58 U.S. MARKET FOR STEM CELL RESEARCH TOOLS, THROUGH 2018 ($
BILLIONS) 122
TABLE 59 REPRESENTATIVE PRICING FOR SAMPLE PREPARATION SERVICES IN CELL
BIOLOGY ($) 123

CHAPTER 9 GLOBAL TARGET MARKETS FOR SAMPLE PREPARATION BY APPLICATION 126

OVERVIEW 126
TABLE 60 GLOBAL MARKET FOR SAMPLE PREPARATION REAGENTS AND PRODUCTS
USED IN LIFE SCIENCE RESEARCH BY SEGMENT, THROUGH 2018 ($ MILLIONS) 126
FOOD SAFETY TESTING 126
TABLE 61 MARKET VALUE OF FOOD SAFETY TESTING FOR PATHOGENS IN THE U.S.,
THROUGH 2018 ($ BILLIONS) 127
ANIMAL HEALTH DIAGNOSTICS 128
TABLE 62 GLOBAL MARKET VALUE OF ANIMAL HEALTH TESTING, THROUGH 2018
($ MILLIONS) 128
FORENSICS AS A TARGET MARKET FOR THE SAMPLE PREPARATION INDUSTRY 129
TABLE 63 U.S. MARKET FOR DNA TESTING SERVICES AND PRODUCTS IN THE
FORENSICS INDUSTRY, 2013 ($ MILLIONS) 130
BIODEFENSE AS A DRIVER MARKET FOR THE SAMPLE PREPARATION INDUSTRY 130

CHAPTER 10 MARKET SUMMARY 133

OVERVIEW 133
TABLE 64 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN GENOMICS,
THROUGH 2018 ($ MILLIONS) 133
FIGURE 3 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN GENOMICS,
2010-2018 ($ MILLIONS) 133
TABLE 65 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
EPIGENOMICS, THROUGH 2018 ($ MILLIONS) 134
FIGURE 4 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
EPIGENOMICS, 2010-2018 ($ MILLIONS) 134
TABLE 66 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
PROTEOMICS, THROUGH 2018 ($ MILLIONS) 135
FIGURE 5 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
PROTEOMICS, 2010-2018 ($ MILLIONS) 135
TABLE 67 MARKET SHARE OF GENOMICS VS. PROTEOMICS SAMPLE PREP
PRODUCTS BY TYPE OF END USER, 2013 (%) 136
MARKET PARTICIPANTS 137
TABLE 68 MAIN MARKET PARTICIPANTS IN THE SAMPLE PREPARATION INDUSTRY
FOR LIFE SCIENCE RESEARCH 138

CHAPTER 11 SELECTED PROFILES OF COMPANIES 142

PROFILES 142
AGILENT TECHNOLOGIES 142
BIO-RAD LABORATORIES, INC. 143
GE HEALTHCARE U.K., LTD. 144
ILLUMINA, INC. 145
MILLIPORE BIOMANUFACTURING AND LIFE SCIENCES (MERCK KGAA) 146
NORGEN BIOTEK 147
PERKIN ELMER 148
PROMEGA CORP. 149
SHIMADZU SCIENTIFIC INSTRUMENTS 150
SIGMA-ALDRICH CORP. 150
THERMO FISHER SCIENTIFIC, INC. 151
QIAGEN 153
WATERS CORPORATION 153
LIST OF COMPANIES 154

LIST OF TABLES

SUMMARY TABLE GLOBAL MARKET FOR SAMPLE PREPARATION REAGENTS AND
PRODUCTS USED IN LIFE SCIENCE RESEARCH BY SEGMENT, THROUGH 2018 ($
MILLIONS)6
TABLE 1 GLOBAL MARKET FOR COMMON REAGENTS AND PRODUCTS IN THE LIFE
SCIENCE TOOLS INDUSTRY BY SEGMENT, THROUGH 2018 ($ BILLIONS) 10
TABLE 2 GLOBAL MARKET SHARES OF THE SAMPLE PREP INDUSTRY BY LIFE
SCIENCE RESEARCH SEGMENT, 2013 (%) 15
TABLE 3 GLOBAL MARKET SHARES OF THE SAMPLE PREP INDUSTRY BY GEOGRAPHIC
REGION, 2013 (%) 16
TABLE 4 PRIOR ART FOR ILLUMINA'S NEWLY ACQUIRED ALL TECHNOLOGY: LAB ON
A CHIP 19
TABLE 5 GLOBAL MARKET FOR GENOMICS PRODUCTS, THROUGH 2018 ($ BILLIONS) 23
TABLE 6 GLOBAL MARKET VALUE OF NUCLEIC ACID EXTRACTION PRODUCTS,
THROUGH 2018 ($ MILLIONS) 26
TABLE 7 NUCLEIC ACID MARKET SHARES BY COMPANY, 2013 (%) 28
TABLE 8 DISTRIBUTION OF THE NUCLEIC ACID PREPARATION MARKET BY TYPE OF
END USER, 2013 (%) 29
TABLE 9 GEOGRAPHIC DISTRIBUTION OF THE NUCLEIC ACID PREPARATION MARKET,
2013 (%) 29
TABLE 10 GLOBAL MARKET SHARES OF RNA ISOLATION PRODUCTS BY COMPANY,
2013 (%) 31
TABLE 11 SELECT COMPANIES PROVIDING PRODUCTS FOR FFPE NUCLEIC ACID
EXTRACTION 34
TABLE 12 DISTRIBUTION OF AUTOMATION DEVICES FOR NUCLEIC ACID
PURIFICATION BY TYPE OF END USER, 2013 (%) 39
TABLE 13 COMPANIES THAT PROVIDE NUCLEIC ACID SAMPLE PREPARATION
PLATFORMS 39
TABLE 14 AVERAGE PRICES OF NUCLEIC ACID PURIFICATION UNITS OFFERED BY
REPRESENTATIVE COMPANIES, 2013 ($) 41
TABLE 15 GLOBAL DNA AMPLIFICATION/PCR MARKET, THROUGH 2018 ($ BILLIONS) 42
TABLE 16 GLOBAL RT-PCR MARKET SHARES BY COMPANY, 2013 (%) 43
TABLE 17 GLOBAL PCR MAKET SHARES BY GEOGRAPHIC REGION, 2013 (%) 44
TABLE 18 SAMPLE PREPARATION MARKET ESTIMATE FOR PCR APPLICATIONS,
THROUGH 2018 ($ MILLIONS) 46
TABLE 19 GLOBAL MARKET FOR DNA SEQUENCING, THROUGH 2018 ($ BILLIONS) 50
TABLE 20 GLOBAL MARKET FOR NGS AND GENERAL SEQUENCING, THROUGH 2018
($ BILLIONS) 51
TABLE 21 NGS MARKET SHARES BY COMPANY, 2013 (%) 53
TABLE 22 CRITERIA FOR CHOOSING A SPECIFIC VENDOR FOR SAMPLE PREP IN NGS
ACCORDING TO PRIORITY (%) 54
TABLE 23 VALUE OF NGS FOR THE SAMPLE PREP MARKET, THROUGH 2018 ($
MILLIONS) 55
TABLE 24 RECENT ACQUISITIONS AND COLLABORATIONS IN THE NGS SAMPLE PREP
INDUSTRY, 2013 57
TABLE 25 MARKET ESTIMATION FOR SAMPLE PREPARATION IN MOLECULAR
CLONING, THROUGH 2018 ($ MILLIONS) 59
TABLE 26 GLOBAL MARKET FOR DNA MICROARRAYS, THROUGH 2018 ($ BILLIONS) 62
TABLE 27 SELECT RNA SYNTHESIS, DEGRADATION AND MODIFICATION PRODUCTS 63
TABLE 28 GLOBAL RNA INTERFERENCE MARKET, THROUGH 2018 ($ MILLIONS) 64
TABLE 29 GLOBAL MARKET FOR DRUG DISCOVERY IN EPIGENOMIC RESEARCH,
THROUGH 2018 ($ BILLIONS) 69
TABLE 30 DIFFERENT CLASSES OF MODIFICATIONS IDENTIFIED ON HISTONES 72
TABLE 31 SELECT EPIGENOMIC PRODUCTS BY SUPPLIER 73
TABLE 32 SELECT EPIGENOMIC SAMPLE PREPARATION PRODUCTS BY SUPPLIER 75
TABLE 33 PRODUCT CATEGORIES FOR EPIGENOMICS RESEARCH, COMPANIES
MARKETING THE PRODUCTS AND AVERAGE PRICES 76
TABLE 34 PERCENTAGE OF COMMERCIAL KITS GENERALLY PURCHASED FOR
EPIGENOMIC RESEARCH BY PRODUCT TYPE (%) 77
TABLE 35 GLOBAL MARKET RESEARCH TOOLS IN THE EPIGENOMIC SEGMENT,
THROUGH 2018 ($ BILLIONS) 77
TABLE 36 DISTRIBUTION OF EPIGENOMIC PRODUCTS IN THE U.S. SAMPLE
PREPARATION INDUSTRY BY TYPE OF END USER, 2013 (%) 78
TABLE 37 STUDIES AND ASSAY DEVELOPMENT IN SPECIFIC DISEASE AREAS (%) 83
TABLE 38 GLOBAL MARKET FOR RESEARCH TOOLS, REAGENTS AND ASSAYS FOR
HISTONE METHYLTRANSFERASE STUDIES, THROUGH 2018 ($ MILLIONS) 89
TABLE 39 SURVEY OF USER-SCIENTISTS' OPINIONS ABOUT EPIGENETICS SCREENING
IN DRUG DISCOVERY (%) 89
TABLE 40 GLOBAL MARKET FOR PROTEOMICS TOOLS, THROUGH 2018 ($ BILLIONS) 92
TABLE 41 PERCENTAGE USE OF SPECIFIC PROTEIN EXPRESSION TECHNIQUES, 2013
(%) 93
TABLE 42 PROTEIN EXPRESSION MARKET SHARES BY COMPANY, 2013 (%) 96
TABLE 43 GLOBAL MARKET FOR PROTEIN CHROMATOGRAPHY, THROUGH 2018 ($
MILLIONS) 100
TABLE 44 AVERAGE SPENDING PER SCIENTIST ON PURIFICATION/ SEPARATION
PRODUCTS ($) 101
TABLE 45 GLOBAL MARKET FOR MASS SPECTROMETRY, THROUGH 2018 ($ MILLIONS) 102
TABLE 46 PERCENTAGE OF TOTAL NMR APPLICATIONS IN VARIOUS SECTORS, 2013
(%) 105
TABLE 47 GLOBAL MARKET FOR 2D GEL ANALYSIS, THROUGH 2018 ($ MILLIONS) 106
TABLE 48 EXAMPLES OF 2D GEL SAMPLE PREPARATION PRODUCTS BY COMPANY,
2013 ($) 107
TABLE 49 GLOBAL PROTEIN CHIP MARKET, THROUGH 2018 ($ MILLIONS) 110
TABLE 50 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
PROTEOMICS, THROUGH 2018 ($ MILLIONS) 111
TABLE 51 CATEGORIES IN THE SAMPLE PREPARATION MARKET FOR PROTEOMICS
RESEARCH AND EXAMPLES OF MARKET PARTICIPANTS 112
TABLE 52 EXAMPLES OF SAMPLE PREPARATION SERVICES FOR PROTEOMICS
RESEARCH AND THEIR AVERAGE COSTS ($) 112
TABLE 53 DISTRIBUTION OF THE PROTEOMICS SAMPLE PREPARATION MARKET BY
TYPE OF END USER, 2013 (%) 113
TABLE 54 GLOBAL MARKET FOR VARIOUS LABELING AND PROBES, 2013 ($ BILLIONS) 116
TABLE 55 GLOBAL MARKET FOR CELL BIOLOGY REAGENTS, THROUGH 2018 ($
BILLIONS) 119
TABLE 56 GLOBAL MARKET SHARES OF CELL BIOLOGY REAGENTS BY PRODUCT
CATEGORY (%) 119
TABLE 57 GLOBAL MARKET FOR FLOW CYTOMETRY, THROUGH 2018 ($ BILLIONS) 121
TABLE 58 U.S. MARKET FOR STEM CELL RESEARCH TOOLS, THROUGH 2018 ($
BILLIONS) 122
TABLE 59 REPRESENTATIVE PRICING FOR SAMPLE PREPARATION SERVICES IN CELL
BIOLOGY ($) 123
TABLE 60 GLOBAL MARKET FOR SAMPLE PREPARATION REAGENTS AND PRODUCTS
USED IN LIFE SCIENCE RESEARCH BY SEGMENT, THROUGH 2018 ($ MILLIONS) 126
TABLE 61 MARKET VALUE OF FOOD SAFETY TESTING FOR PATHOGENS IN THE U.S.,
THROUGH 2018 ($ BILLIONS) 127
TABLE 62 GLOBAL MARKET VALUE OF ANIMAL HEALTH TESTING, THROUGH 2018 ($
MILLIONS) 128
TABLE 63 U.S. MARKET FOR DNA TESTING SERVICES AND PRODUCTS IN THE
FORENSICS INDUSTRY, 2013 ($ MILLIONS) 130
TABLE 64 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN GENOMICS,
THROUGH 2018 ($ MILLIONS) 133
TABLE 65 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
EPIGENOMICS, THROUGH 2018 ($ MILLIONS) 134
TABLE 66 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
PROTEOMICS, THROUGH 2018 ($ MILLIONS) 135
TABLE 67 MARKET SHARE OF GENOMICS VS. PROTEOMICS SAMPLE PREP PRODUCTS
BY TYPE OF END USER, 2013 (%) 136
TABLE 68 MAIN MARKET PARTICIPANTS IN THE SAMPLE PREPARATION INDUSTRY
FOR LIFE SCIENCE RESEARCH 138

LIST OF FIGURES

SUMMARY FIGURE GLOBAL MARKET FOR SAMPLE PREPARATION REAGENTS AND
PRODUCTS USED IN LIFE SCIENCE RESEARCH BY SEGMENT, 2010-2018 ($ MILLIONS) 6
FIGURE 1 GENOME AND GENE ANALYSIS WORKFLOW 11
FIGURE 2 PROTEIN ANALYSIS WORKFLOW 12
FIGURE 3 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN GENOMICS,
2010-2018 ($ MILLIONS) 133
FIGURE 4 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
EPIGENOMICS, 2010-2018 ($ MILLIONS) 134
FIGURE 5 MARKET ESTIMATE FOR SAMPLE PREPARATION PRODUCTS IN
PROTEOMICS, 2010-2018 ($ MILLIONS) 135

Read the full report:
Sample Preparation in Genomics, Proteomics, and Epigenomics: Global Markets

http://www.reportbuyer.com/pharma_healthcare/diseases/sample_preparation_genomics_proteomics_epigenomics.html

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Email: query@reportbuyer.com  
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