DETROIT (AP)Buffalo Bills edge rusher Von Miller had a knee injury in the second quarter and was ruled out for the rest of the game against the Detroit Lions.

Miller was evaluated on the sideline and was taken on a cart from the sideline to the locker room.

Miller had one tackle and was credited with hurrying quarterback Jared Goff before leaving the game Thursday.

The 33-year-old Miller entered the game tied for 10th in the NFL with eight sacks.

His injury was another setback for a banged-up defense that was without injured defensive ends Greg Rousseau and A.J. Epenesa along with linebacker Tremaine Edmunds.

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